Hydrochloric Acid → 2-Methyl-5-(4-phenethyl-piperazin-1-ylmethyl)-pyrimidin-4-ylamine hydrochloride

HRID 2294027ノート

反応式

HRID 2294027 の反応式
[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:12][CH2:11]2)=[CH:4][N:3]=1.[ClH:24]>CO>[ClH:24].[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][N:10]2[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:14][CH2:15]2)=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 214736142-Methyl-5-(4-phenethyl-piperazin-1-ylmethyl)-pyrimidin-4-ylamine

生成物 1

HCID 214737132-Methyl-5-(4-phenethyl-piperazin-1-ylmethyl)-pyrimidin-4-ylamine hydrochloride収率 87%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 0.37 g (0.0012 mol) of 2-methyl-5-(4-phenethyl-piperazin-1-ylmethyl)-pyrimidin-4-ylamine in 20 ml of methanol was treated with 0.37 ml (0.00129 mol) of 3.5N ethanolic hydrochloric acid, The solution was completely freed from the solvents and the residue was recrystallized from ethanol. 0.36 g (87%) of 2-methyl-5-(4-phenethyl-piperazin-1-ylmethyl)-pyrimidin-4-ylamine hydrochloride (1:1.2) was obtained as white crystals; m.p. 240°-242°.

後処理

  1. customthe residue was recrystallized from ethanol

出典と根拠

ORDレコード
ord-00c4f20c742949b193696e7c20ead8da
出典データセット
uspto-grants-1997_11
特許番号
US05688798

反応ノート

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