Hydrochloric Acid → 5-(4-Phenyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride

HRID 2294033ノート

反応式

HRID 2294033 の反応式
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[C:15]([NH2:21])=[N:16][C:17]([NH2:20])=[N:18][CH:19]=3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:22]>CO>[ClH:22].[ClH:22].[C:1]1([N:7]2[CH2:8][CH2:9][N:10]([CH2:13][C:14]3[C:15]([NH2:21])=[N:16][C:17]([NH2:20])=[N:18][CH:19]=3)[CH2:11][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 214736725-(4-Phenyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine

生成物 1

HCID 214737025-(4-Phenyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride収率 99.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

0.17 g (0.00059 mol) of 5-(4-phenyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine was dissolved in 120 ml of hot methanol. The solution was treated at room temperature with 0.32 ml (0.00118 mol) of 3.7N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from methanol/diethyl ether. 0.21 g (71%) of 5-(4-phenyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride was obtained as white crystals; m.p. 275°-277°.

後処理

  1. customthe residue was recrystallized from methanol/diethyl ether

出典と根拠

ORDレコード
ord-945448211fc845539079e982daa62383
出典データセット
uspto-grants-1997_11
特許番号
US05688798

反応ノート

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