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Hydrochloric Acid → 5-(4-p-Tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 5-(4-p-Tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine | HCID 21473633 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 5-(4-p-Tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride | HCID 21473632 | 77% |
反応手順
0.23 g (0.00077 mol) of 5-(4-p-tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine was dissolved in 220 ml of hot methanol. The solution was treated at room temperature with 0.44 ml (0.00154 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from ethanol/diethyl ether. 0.22 g (77%) of 5-(4-p-tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride was obtained as whited crystals; m.p. 220°-222°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05688798 |
| 出典データセット | uspto-grants-1997_11 |
| ORD ID | ord-60f3192f14224afc936563c5caeac9ae |
| 出典メモ | uspto-grants-1997_11 |