Hydrochloric Acid → 5-[4-(4-Methoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine hydrochloride

HRID 2294039ノート

反応式

HRID 2294039 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[C:17]([NH2:23])=[N:18][C:19]([NH2:22])=[N:20][CH:21]=3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[ClH:24]>CO>[ClH:24].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:10][CH2:11][N:12]([CH2:15][C:16]3[C:17]([NH2:23])=[N:18][C:19]([NH2:22])=[N:20][CH:21]=3)[CH2:13][CH2:14]2)=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 214736195-[4-(4-Methoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine

生成物 1

HCID 214736185-[4-(4-Methoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine hydrochloride収率 105.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

0.23 g (0.00073 mol) of 5-[4-(4-methoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine was dissolved in 250 ml of hot methanol. The solution was treated at room temperature with 0.84 ml (0.00293 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and recrystallized from methanol/diethyl ether. 0.27 g (96%) of 5-[4-(4-methoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine hydrochloride (1:2.3) was obtained as white crystals; m.p. 215°-216°.

後処理

  1. customrecrystallized from methanol/diethyl ether

出典と根拠

ORDレコード
ord-c7d476bda2394c02a6f3f9a7f7daf958
出典データセット
uspto-grants-1997_11
特許番号
US05688798

反応ノート

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