HCID 54429599、化合物 → 2-(2-Fluorophenyl)oxazole
反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:9][CH2:10][CH2:11][N:12]=1>C1C=CC=CC=1.O.OO.[Ni]>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:9][CH:10]=[CH:11][N:12]=1参加物
4
実験手順
A mixture of 2-fluoro-1-(4,5-dihydrooxazol-2-yl)benzene (4.5 g, 27.3 mmol) and nickel peroxide hydrate (7 g) in 40 mL of benzene was heated at reflux for 24 hours. The mixture was allowed to cool to room temperature, filtered and concentrated by rotary evaporation. The residue was purified on silica gel by column chromatography eluting with hexanes/ethyl acetate (5:1) to give 2-fluoro-1-oxazol-2-yl-benzene (0.5 g, 3.07 mmol).
後処理
- temperaturewas heated
- temperatureat reflux for 24 hours
- filtrationfiltered
- concentrationconcentrated by rotary evaporation
- customThe residue was purified on silica gel by column chromatography
- washeluting with hexanes/ethyl acetate (5:1)
出典と根拠
- ORDレコード
- ord-3db6a156205542db89498a3c235f51ea
- 出典データセット
- uspto-grants-1997_11
- 特許番号
- US05688795
反応ノート
読み込み中…