Urea → 5-Chloroquinazoline-2,4-diol

HRID 2294169ノート

反応式

HRID 2294169 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:3]=1[C:4](O)=[O:5].[NH2:12][C:13](N)=[O:14]>>[Cl:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:2]2[C:3]=1[C:4](=[O:5])[NH:12][C:13](=[O:14])[NH:1]2

参加物

3

反応物 2

HCID 1176UreaHCID 750712-Amino-6-chlorobenzoic acid

生成物 1

HCID 3340215-Chloroquinazoline-2,4-diol収率 55.5%

反応条件

温度
160 °C

実験手順

A mixture of 2.0 g (11 mmol) of 2-amino-6-chlorobenzoic acid and 1.4 g (23 mmol) of urea was heated to 160° C. for 2 hrs. and at 180° C. for a further 2 hrs. The resulting brown mass was triturated with 200 ml of methanol, filtered off and dried in a vacuum. 1.2 g (53%) of 5-chloro-1,2,3,4-tetrahydroquinazoline-2,4-dione were obtained as white crystals;

後処理

  1. customThe resulting brown mass was triturated with 200 ml of methanol
  2. filtrationfiltered off
  3. customdried in a vacuum

出典と根拠

ORDレコード
ord-0bf54a60f66f4a54be903b868cdadb7c
出典データセット
uspto-grants-1997_11
特許番号
US05688803

反応ノート

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