Ammonia → HCID 21474046、化合物

HRID 2294183ノート

反応式

HRID 2294183 の反応式
[NH2:1][C:2]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[C:9]([F:15])=[CH:8][C:3]=1[C:4](OC)=[O:5].[NH3:16]>CO>[NH2:1][C:2]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[C:9]([F:15])=[CH:8][C:3]=1[C:4]([NH2:16])=[O:5]

参加物

4

反応物 2

HCID 222AmmoniaHCID 21473985HCID 21473985、化合物

生成物 1

HCID 21474046HCID 21474046、化合物収率 85%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

4.0 g (18.7 mmol) of methyl 2-amino-5-fluoro-4-nitro-benzoate were dissolved in 250 ml of methanol and saturated with ammonia at -40° C. Subsequently, the mixture was stirred at room temperature overnight. The solution was concentrated and ther residue was triturated with methylene chloride. The precipitate was filtered off under suction and dried. 3.17 g (85%) of 2-amino-5-fluoro-4-nitro-benzamide were obtained as yellow crystals;

後処理

  1. concentrationThe solution was concentrated
  2. customther residue was triturated with methylene chloride
  3. filtrationThe precipitate was filtered off under suction
  4. customdried

出典と根拠

ORDレコード
ord-1f62b12db0bc4c628c6b6d06335b7b16
出典データセット
uspto-grants-1997_11
特許番号
US05688803

反応ノート

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