Ammonia → HCID 21474075、化合物

HRID 2294192ノート

反応式

HRID 2294192 の反応式
[NH2:1][C:2]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[C:9]([Br:15])=[CH:8][C:3]=1[C:4](OC)=[O:5].[NH3:16]>CO>[NH2:1][C:2]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[C:9]([Br:15])=[CH:8][C:3]=1[C:4]([NH2:16])=[O:5]

参加物

4

反応物 2

HCID 222AmmoniaHCID 21474098HCID 21474098、化合物

生成物 1

HCID 21474075HCID 21474075、化合物収率 75%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

25.8 g (93.8 mmol) of methyl 2-amino-5-bromo-4-nitro-benzoate were dissolved in 800 ml of methanol and saturated with ammonia at -40° C. Subsequently, the mixture was stirred at room temperature overnight. The solution was concentrated and the residue was triturated with methylene chloride. The precipitate was filtered off under suction and dried. 18.3 g (75%) of 2-amino-5-bromo-4-nitro-benzamide were obtained as orange coloured crystals;

後処理

  1. concentrationThe solution was concentrated
  2. customthe residue was triturated with methylene chloride
  3. filtrationThe precipitate was filtered off under suction
  4. customdried

出典と根拠

ORDレコード
ord-9b69b947b99b4ce18f1093ce412613ad
出典データセット
uspto-grants-1997_11
特許番号
US05688803

反応ノート

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