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Methanol → 3-(8-Phenyloctyloxy)-2-hydroxypropylazide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Methyl formate | HCID 7865 | — |
| 反応物 | Sodium Azide | HCID 33557 | — |
| 反応物 | 8-Phenyloctyloxymethyloxirane | HCID 21474710 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-(8-Phenyloctyloxy)-2-hydroxypropylazide | HCID 21474713 | 96.7% |
反応手順
A procedure similar to that described in Preparation 12 was repeated, except that 2.4 g of 8-phenyloctyloxymethyloxirane (prepared as described in Preparation 64), 2.97 g of sodium azide, 20 ml of methyl formate and 80 ml of an 8:1 by volume mixture of methanol and water were used, to give 2.7 g of the title compound having an Rf value of 0.29 (on silica gel thin layer chromatography, using a 1:5 by volume mixture of ethyl acetate and hexane as the developing solvent).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05688823 |
| 出典データセット | uspto-grants-1997_11 |
| ORD ID | ord-0e72fa836a4a4791a92087d1a49e55af |
| 出典メモ | uspto-grants-1997_11 |