Maleic Anhydride → 2-(3-Carboxy-acryloylamino)-4,5-dimethyl-thiophene-3-carboxylic acid ethyl ester

HRID 229450

反応式

HRID 229450 の反応式
[CH2:1]([O:3][C:4]([C:6]1[C:10]([CH3:11])=[C:9]([CH3:12])[S:8][C:7]=1[NH2:13])=[O:5])[CH3:2].[C:14]1(=[O:20])[O:19][C:17](=[O:18])[CH:16]=[CH:15]1>CCOCC>[CH2:1]([O:3][C:4]([C:6]1[C:10]([CH3:11])=[C:9]([CH3:12])[S:8][C:7]=1[NH:13][C:14](=[O:20])[CH:15]=[CH:16][C:17]([OH:19])=[O:18])=[O:5])[CH3:2]

参加物

4

反応物 2

HCID 7923Maleic AnhydrideHCID 78536Ethyl 2-amino-4,5-dimethyl3-thenoate

生成物 1

HCID 6815482-(3-Carboxy-acryloylamino)-4,5-dimethyl-thiophene-3-carboxylic acid ethyl ester収率 72.1%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

A solution of 2-Amino-4,5-dimethyl-thiophene-3-carboxylic acid ethyl ester (5.53 g, 27.8 mmol) in 25 mL of anhydrous ether was added dropwise to a solution of maleic anhydride (2.72 g, 27.8 mmol) in 25 mL of anhydrous ether. The reaction mixture was stirred at room temperature for 10 h. A yellow precipitate was formed. 2-(3-Carboxy-acryloylamino)-4,5-dimethyl-thiophene-3-carboxylic acid ethyl ester (5.96 g, 72% yield) was obtained as a yellow solid by filtration.

後処理

  1. customA yellow precipitate was formed

出典と根拠

ORDレコード
ord-a4a3581e4ffb45af8cc9c9132ec0117b
出典データセット
uspto-grants-2009_07
特許番号
US07563813B2

関連ノート

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