Lithium hydroxide, monohydrate → HCID 10432719、化合物

HRID 2294740ノート

反応式

HRID 2294740 の反応式
O.[OH-].[Li+].C[O:5][C:6](=[O:35])[C@H:7]([CH2:26][C:27]1[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=1)[NH:8][C:9](=[O:25])[CH2:10][C:11]([NH:14][C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16])([CH3:13])[CH3:12]>O.O1CCOCC1>[CH2:18]([O:17][C:15]([NH:14][C:11]([CH3:13])([CH3:12])[CH2:10][C:9]([NH:8][C@H:7]([C:6]([OH:35])=[O:5])[CH2:26][C:27]1[CH:28]=[CH:29][C:30]([O:33][CH3:34])=[CH:31][CH:32]=1)=[O:25])=[O:16])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

参加物

5

反応物 2

HCID 168937Lithium hydroxide, monohydrateHCID 10026366HCID 10026366、化合物

生成物 1

HCID 10432719HCID 10432719、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 312751,4-Dioxane溶媒

実験手順

0.184 g (4.39 mmol) of lithium hydroxide hydrate dissolved in 8 ml of water is added dropwise to a solution of 1.7 g (3.84 mmol) of N-[3-[1-(benzyloxy)formamido]-3-methylbutyryl]-3-(p-methoxyphenyl)-L-alanine methyl ester in 16 ml of dioxan. The solution is stirred at 0° for 1 hour, then treated with 20 ml of water and extracted twice with ether. The aqueous phase is acidified with 6N hydrochloric acid and extracted twice with ether. The combined ether extracts are washed with saturated sodium chloride solution, dried over sodium sulphate and then evaporated under reduced pressure. N-[3-[1-(Benzyloxy)formamido]-3-methylbutyryl]-3-(p-methoxyphenyl)-L-alanine is obtained as a colourless oil, MS: 429 (M+H)+.

後処理

  1. extractionextracted twice with ether
  2. extractionextracted twice with ether
  3. washThe combined ether extracts are washed with saturated sodium chloride solution
  4. dry with materialdried over sodium sulphate
  5. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-0eaab0bb252f4f46986de6e2a8dc6503
出典データセット
uspto-grants-1997_11
特許番号
US05688946

反応ノート

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