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Dibutyl squarate → 1-Benzyloxycarbonyl-4-(4-butoxy-1,2-dioxo-3-cyclobuten-3-yl)-piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dibutyl squarate | HCID 65108 | — |
| 反応物 | Benzyl piperazine-1-carboxylate | HCID 643495 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-Benzyloxycarbonyl-4-(4-butoxy-1,2-dioxo-3-cyclobuten-3-yl)-piperazine | HCID 22591375 | 84.3% |
反応手順
A mixture comprising 1101 mg of N-benzyloxycarbonylpiperazine, 1131 mg of 3,4-dibutoxy-3-cyclobutene-1,2-dione and 5 ml of ethanol was stirred at room temperature for 25 hours. The reaction mixture was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (solvent: chloroform-ethyl acetate (19:1)) to obtain 1570 mg of 1-benzyloxycarbonyl-4-(4-butoxy-1,2-dioxo-3-cyclobuten-3-yl)-piperazine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06849622B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-5d8f2845c5944acb8f74eeb878fb6fd8 |
| 出典メモ | uspto-grants-2005_02 |