6-Acetyl-2-(2-chloroethyl)-4,5,6,7-tetrahydro-3-methylthieno[2,3-c]pyridine → 6-Acetyl-2-(2-(4-(6-fluorobenzo(b)thiophen-3-yl)piperidin-1-yl)ethyl)-4,5,6,7-tetrahydro-3-methylthieno[2,3-c]pyridine

HRID 2294862ノート

反応式

HRID 2294862 の反応式
[C:1]([N:4]1[CH2:9][CH2:8][C:7]2[C:10]([CH3:16])=[C:11]([CH2:13][CH2:14]Cl)[S:12][C:6]=2[CH2:5]1)(=[O:3])[CH3:2].Cl.[F:18][C:19]1[CH:20]=[CH:21][C:22]2[C:26]([CH:27]3[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]3)=[CH:25][S:24][C:23]=2[CH:33]=1>>[C:1]([N:4]1[CH2:9][CH2:8][C:7]2[C:10]([CH3:16])=[C:11]([CH2:13][CH2:14][N:30]3[CH2:31][CH2:32][CH:27]([C:26]4[C:22]5[CH:21]=[CH:20][C:19]([F:18])=[CH:33][C:23]=5[S:24][CH:25]=4)[CH2:28][CH2:29]3)[S:12][C:6]=2[CH2:5]1)(=[O:3])[CH3:2]

参加物

3

反応物 2

HCID 214717636-Acetyl-2-(2-chloroethyl)-4,5,6,7-tetrahydro-3-methylthieno[2,3-c]pyridineHCID 226493344-(6-Fluorobenzo(b)thiophen-3-yl)piperidine hydrochloride

生成物 1

HCID 214719076-Acetyl-2-(2-(4-(6-fluorobenzo(b)thiophen-3-yl)piperidin-1-yl)ethyl)-4,5,6,7-tetrahydro-3-methylthieno[2,3-c]pyridine

実験手順

The reaction and procedure are conducted in a similar manner as in Example 24 using 6-acetyl-2-(2-chloroethyl)-4,5,6,7-tetrahydro-3-methylthieno[2,3-c]pyridine and 4-(6-fluorobenzo(b)thiophen-3-yl)piperidine hydrochloride to give 6-acetyl-2-(2-(4-(6-fluorobenzo(b)thiophen-3-yl)piperidin-1-yl)ethyl)-4,5,6,7-tetrahydro-3-methylthieno[2,3-c]pyridine.

後処理

  1. customThe reaction and procedure

出典と根拠

ORDレコード
ord-1bf06c94e044411692aa9eda39525993
出典データセット
uspto-grants-1997_11
特許番号
US05691330

反応ノート

読み込み中…