Diethylamine → HCID 86751671、化合物

反応式

[CH2:1]([C:5]1[N:22]([CH2:23][C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[C:36]3[N:40]([CH:41]([O:43][CH2:44][CH3:45])[CH3:42])[N:39]=[N:38][N:37]=3)=[CH:26][CH:25]=2)[C:8]2=[N:9][C:10]([C:19]([OH:21])=[O:20])=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=3)[CH:12]=[C:7]2[N:6]=1)[CH2:2][CH2:3][CH3:4].C(NCC)C>C(Cl)Cl.CN(C1C=CN=CC=1)C>[CH2:5]([N-:6][CH2:7][CH3:12])[CH3:1].[CH2:1]([C:5]1[N:22]([CH2:23][C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[C:36]3[N:40]([CH:41]([O:43][CH2:44][CH3:45])[CH3:42])[N:39]=[N:38][N:37]=3)=[CH:26][CH:25]=2)[C:8]2=[N:9][C:10]([C:19]([O-:21])=[O:20])=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=3)[CH:12]=[C:7]2[N:6]=1)[CH2:2][CH2:3][CH3:4]

参加物

実験手順

80 mg (0.13 mmole) of the compound obtained in step 1 was dissolved in 2 ml of CH2Cl2 and to the resulting solution were added 12 mg (0.16 mmole) of diethylamine, 33 mg (0.16 mmole) of DDC(Dithiocarb Sodium) and 2 mg (0.016 mmole) of DMAP. The resultant was stirred for 16 hours at room temperature and evaporated under reduced pressure to remove the residual solvent. The residue was purified with column chromatography (ethyl acetate) to obtain 34 mg of the title compound (yield 40%).