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Hydrochloric Acid → 4-(Dimethylamino)piperidine dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Dimethylamine, hydrochloride | HCID 10473 | — |
| 反応物 | Triacetoxyborohydride | HCID 2724942 | — |
| 反応物 | 4-Boc-piperidinone | HCID 22318161 | — |
| 反応物 | Tert-butyl 4-(dimethylamino)piperidine-1-carboxylate | HCID 22591376 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 4-(Dimethylamino)piperidine dihydrochloride | HCID 22591440 | — |
反応手順
Dimethylamine hydrochloride (430 mg) was added to a methylene chloride (10 ml) solution containing 4-(tert-butoxycarbonyl)piperidone (1.0 g), and under ice-cooling, triethylamine (0.84 ml) and triacetoxyborohydride (1.17 g) were further added thereto, and the mixture was stirred at room temperature for 3 hours to undergo reaction, thereby obtaining N-tert-butoxycarbonyl-4-dimethylaminopiperidine. This compound was acid-treated with hydrochloric acid to obtain 4-(dimethylamino)piperidine.dihydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06849622B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-2a621ec232ee49fcbfb7856de2c1ed48 |
| 出典メモ | uspto-grants-2005_02 |