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Hydrochloric Acid → 1-(Cyclohexylmethyl)piperazine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1-Piperazinecarboxaldehyde | HCID 82191 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 反応物 | 1-Formyl-4-cyclohexylmethylpiperazine | HCID 22591423 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-(Cyclohexylmethyl)piperazine hydrochloride | HCID 22591386 | — |
反応手順
Sodium triacetoxyborohydride (10.51 g) was added to a methylene chloride (50 ml) solution containing N-formylpiperazine (5.08 g) and cyclohexanecarboxyaldehyde (7.50 g) under ice-cooling, and the mixture was stirred at room temperature for 18 hours to undergo reaction, thereby obtaining 1-formyl-4-cyclohexylmethylpiperazine, which was then acid-treated with hydrochloric acid to obtain 1-(cyclohexylmethyl)piperazine.hydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06849622B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-297bfe60233642e4b473882bdbf3e196 |
| 出典メモ | uspto-grants-2005_02 |