2-Mercaptobenzoic Acid → S-(1-isoquinolyl-methyl)-2-mercapto-benzoic acid

反応式

Cl[CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][N:4]=1.[C:13]([OH:22])(=[O:21])[C:14]1[C:15](=[CH:17][CH:18]=[CH:19][CH:20]=1)[SH:16]>>[C:3]1([CH2:2][S:16][C:15]2[CH:17]=[CH:18][CH:19]=[CH:20][C:14]=2[C:13]([OH:22])=[O:21])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][N:4]=1

参加物

反応物 2

HCID 54432-Mercaptobenzoic Acid

HCID 132210311-(Chloromethyl)isoquinoline

生成物 1

HCID 57295078S-(1-isoquinolyl-methyl)-2-mercapto-benzoic acid

実験手順

Following the procedure described in Example 16 but starting from 1.8 g. of 1-chloromethyl-isoquinoline and 1.54 g. of thiosalicylic acid, 1.1 g. of S-(1-isoquinolyl-methyl)-2-mercapto-benzoic acid are obtained, melting at 170° to 172° C.

出典と根拠

ORDレコード: ord-3cd7959fe43f4c8596ee4585ee319dc9
出典データセット: uspto-grants-1984_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04425349

反応ノート

読み込み中…