Hydrochloric Acid → HCID 13316896、化合物

HRID 2295521ノート

反応式

HRID 2295521 の反応式
Cl.C([S:5][CH2:6][CH2:7][C:8]([N:10]1[C@H:14]([C:15]([NH:17][C@H:18]([C:21]([OH:23])=[O:22])[CH2:19][OH:20])=[O:16])[CH2:13][S:12][C@@H:11]1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[OH:30])=[O:9])(=O)C>O.N>[OH:30][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1[C@@H:11]1[N:10]([C:8](=[O:9])[CH2:7][CH2:6][SH:5])[C@H:14]([C:15]([NH:17][C@H:18]([C:21]([OH:23])=[O:22])[CH2:19][OH:20])=[O:16])[CH2:13][S:12]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 13316867HCID 13316867、化合物

生成物 1

HCID 13316896HCID 13316896、化合物収率 88%

試薬・触媒・溶媒 1

HCID 12896473Azane;hydrate溶媒

実験手順

In 10 ml of 28% ammonia water 0.5 g of (2S)-N-[(2R,4R)-[3-(S-acetyl-3-mercaptopropanoyl)-2-(2-hydroxyphenyl)-4-thiazolidinyl]carbonyl]serine is dissolved. The solution is stirred at room temperature for 30 minutes, and acidified with hydrochloric acid after removing excess ammonia. The separated oil is extracted with ethyl acetate. The organic layer is washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and ethyl acetate is removed to give 0.4 g (88%) of the titled compound.

後処理

  1. customafter removing excess ammonia
  2. extractionThe separated oil is extracted with ethyl acetate
  3. washThe organic layer is washed with saturated aqueous sodium chloride solution
  4. dry with materialdried over anhydrous magnesium sulfate, and ethyl acetate
  5. customis removed

出典と根拠

ORDレコード
ord-3a38fe4b66034452ab42f6eb7bc45767
出典データセット
uspto-grants-1984_01
特許番号
US04425333

反応ノート

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