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Hydrochloric Acid → 1-(N-methyl-N-phenylaminocarbonyl)piperazine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Carbamic chloride, N-methyl-N-phenyl- | HCID 77969 | — |
| 反応物 | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 1-(N-methyl-N-phenylaminocarbonyl)piperazine hydrochloride | HCID 22591369 | — |
反応手順
An acetonitrile (7 ml) solution containing N-(tert-butoxycarbonyl)piperazine (700 mg), N-methyl-N-phenylcarbamoyl chloride (700 mg) and triethylamine (1.05 mL) was stirred at room temperature for 15 hours to undergo reaction, and the resulting compound was acid-treated with hydrochloric acid to obtain 1-(N-methyl-N-phenylaminocarbonyl)piperazine.hydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06849622B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-e805a6f4dfc941a1bf33986745408cfb |
| 出典メモ | uspto-grants-2005_02 |