Water → 4-Isopropylphenylacetonitrile
反応式
[CH:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Cl)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[C-:12]#[N:13].[Na+].O>CN(C)C=O>[CH:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8][C:12]#[N:13])=[CH:6][CH:5]=1)([CH3:3])[CH3:2]参加物
5
反応条件
- 温度
- 70 °C
実験手順
To a stirred solution of 100 g of 4-isopropylbenzyl chloride in 1500 mL of N,N-dimethylformamide was added 32.0 g of sodium cyanide under ice-cooling. The mixture was stirred at 70° C. for 4 hours, and water was added to the reaction mixture. The mixture was extracted with ethyl acetate, and the organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give 96.5 g of (4-isopropylphenyl)acetonitrile.
後処理
- temperaturecooling
- extractionThe mixture was extracted with ethyl acetate
- washthe organic layer was washed with water and brine
- dry with materialdried over anhydrous magnesium sulfate
- customThe solvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-9df1e22e76ea4d78b29edcb781d8aa95
- 出典データセット
- uspto-grants-2009_07
- 特許番号
- US07563822B2
反応ノート
読み込み中…