HCID 86738654、化合物 → HCID 67880269、化合物
反応式
[C:1]([O:4][C@H:5]1[CH2:22][C@@:20]2([CH3:21])[C@@H:16]([CH2:17][CH2:18][C:19]2(SCC)[S:23][CH2:24][CH3:25])[C@H:15]2[C@@:6]1([F:31])[C@:7]1([CH3:30])[C:12]([CH2:13][CH2:14]2)=[CH:11][C:10](=[O:29])[CH:9]=[CH:8]1)(=[O:3])[CH3:2]>C(C1C=CC=CC=1CC)C>[C:1]([O:4][C@H:5]1[CH2:22][C@@:20]2([CH3:21])[C@@H:16]([CH2:17][CH:18]=[C:19]2[S:23][CH2:24][CH3:25])[C@H:15]2[C@@:6]1([F:31])[C@:7]1([CH3:30])[C:12]([CH2:13][CH2:14]2)=[CH:11][C:10](=[O:29])[CH:9]=[CH:8]1)(=[O:3])[CH3:2]参加物
3
反応条件
- 温度
- 180 °C
実験手順
A suspension of 5.2 g of 11β-(acetyloxy)-17,17-bis(ethylthio)-9-fluoroandrosta-1,4-dien-3-one in 85 ml of dry diethylbenzene was stirred at 180° C. (oil bath temperature) for 1.0 hour; the suspension gradually became a homogeneous solution during the heating. The resulting solution was cooled to 0° C. and the solid that precipitated was filtered and dried in vacuo to give 3.6 g of the title compound, melting point 211°-214° C.