Hydrochloric Acid → HCID 70514525、化合物
反応式
[NH2:1][C:2]1[C:3]([C:10]([OH:12])=[O:11])=[CH:4][S:5][C:6]=1[CH2:7][CH2:8][CH3:9].[ClH:13].[CH2:14](O)[CH3:15]>>[ClH:13].[CH2:14]([O:11][C:10]([C:3]1[C:2]([NH2:1])=[C:6]([CH2:7][CH2:8][CH3:9])[S:5][CH:4]=1)=[O:12])[CH3:15]参加物
4
実験手順
A sample of 1.50 g. (8.097 mmols) of 4-amino-5-propyl-3-thiophenecarboxylic acid was dissolved in 75 ml. absolute ethanol which had been previously saturated with gaseous hydrogen chloride. The resulting reaction was heated under reflux for 24 hours, cooled and evaporated to afford 1.43 g. (71%) of pure 4-amino-5-propyl-3-thiophenecarboxylic acid ethyl ester hydrochloride, m.p. 144° C. (dec.) after recrystallization from ethyl acetate.
後処理
- customThe resulting reaction
- temperaturewas heated
- temperatureunder reflux for 24 hours
- temperaturecooled
- customevaporated
- customto afford 1.43 g
- custom(71%) of pure 4-amino-5-propyl-3-thiophenecarboxylic acid ethyl ester hydrochloride, m.p. 144° C. (dec.) after recrystallization from ethyl acetate
出典と根拠
- ORDレコード
- ord-d4d7f0fe0b3a4170ade8d319d8eadb8a
- 出典データセット
- uspto-grants-1984_01
- 特許番号
- US04428963
反応ノート
読み込み中…