Hydrochloric Acid → HCID 70515775、化合物

HRID 2296361ノート

反応式

HRID 2296361 の反応式
[NH2:1][C:2]1[C:3]([C:9]([OH:11])=[O:10])=[CH:4][S:5][C:6]=1[CH2:7][CH3:8].[ClH:12].[CH:13](O)([CH3:15])[CH3:14]>>[ClH:12].[CH:13]([O:10][C:9]([C:3]1[C:2]([NH2:1])=[C:6]([CH2:7][CH3:8])[S:5][CH:4]=1)=[O:11])([CH3:15])[CH3:14]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 132861554-Amino-5-ethylthiophene-3-carboxylic acid

生成物 1

HCID 70515775HCID 70515775、化合物

実験手順

A sample of 1.02 g. (4.610 mmols) of 4-amino-5-ethyl-3-thiophenecarboxylic acid was dissolved in 50 ml. of isopropanol which had been previously saturated with gaseous hydrogen chloride. The resulting reaction was heated under reflux for 48 hours, cooled and evaporated to afford 0.927 g. (81%) of pure 4-amino-5-ethyl-3-thiophenecarboxylic acid isopropyl ester hydrochloride, m.p. 159° C. (dec.) after recrystallization from isopropanol/ether.

後処理

  1. customThe resulting reaction
  2. temperaturewas heated
  3. temperatureunder reflux for 48 hours
  4. temperaturecooled
  5. customevaporated
  6. customto afford 0.927 g
  7. custom(81%) of pure 4-amino-5-ethyl-3-thiophenecarboxylic acid isopropyl ester hydrochloride, m.p. 159° C. (dec.) after recrystallization from isopropanol/ether

出典と根拠

ORDレコード
ord-1c52abc27833412ba0bf8c7fdfbb86a5
出典データセット
uspto-grants-1984_01
特許番号
US04428963

反応ノート

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