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Phenol → 3,5-Dichloroaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenol | HCID 996 | — |
| 反応物 | Quintozene | HCID 6720 | — |
| 反応物 | 2,3,4,5-Tetrachloronitrobenzene | HCID 13428 | — |
| 反応物 | Hydrogen iodide | HCID 24841 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 生成物 | 3,5-Dichloroaniline | HCID 12281 | 92% |
反応手順
150 parts of a mixture of tetrachloronitrobenzene and pentachloronitrobenzene, the composition of which corresponds to that of the polychloroaniline mixture of Example 3, 200 parts of phenol and 10 parts of aqueous hydroiodic acid (57% strength) are reacted with hydrogen in the presence of 20 parts of ruthenium-on-charcoal catalyst (5% strength), starting at approximately 60° C. to a maximum of 165° C. under a pressure of 20 bars, at the beginning, to a maximum of 50 bars, during the course of 10 hours. After working up, 84.5 parts of 3,5-dichloroaniline are obtained. Yield 92% of theory.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04429156 |
| 出典データセット | uspto-grants-1984_01 |
| ORD ID | ord-5cc84778a7c1483c983775589705cc42 |
| 出典メモ | uspto-grants-1984_01 |