Hydrochloric Acid → HCID 10219906、化合物

HRID 2296779ノート

反応式

HRID 2296779 の反応式
C(OC([N:8]1[CH2:11][C:10]2([CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[CH:9]1[C:17]([OH:19])=[O:18])=O)(C)(C)C.C(OCC)(=O)C.[ClH:26]>>[ClH:26].[CH:9]1([C:17]([OH:19])=[O:18])[C:10]2([CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[CH2:11][NH:8]1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 183350452-[(tert-Butoxy)carbonyl]-2-azaspiro[3.5]nonane-1-carboxylic acid

生成物 1

HCID 10219906HCID 10219906、化合物収率 92%

実験手順

Compound 8 (21.5 mg; 0.079 mmol) was dissolved in a dry 1 M HCl(g) solution in ethyl acetate (0.4 mL; 0.4 mmol) under an argon atmosphere. The reaction mixture was stirred at room temperature for 5 hours. The white precipitate was collected by filtration and washed several times with dry diethyl ether (2 mL) and dried under vacuum to give 9 as a white powder (15.2 mg; 0.074 mmol; 92%).

後処理

  1. filtrationThe white precipitate was collected by filtration
  2. washwashed several times with dry diethyl ether (2 mL)
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-0959682982464354807355498af436a6
出典データセット
uspto-grants-2002_12
特許番号
US06489352B2

反応ノート

読み込み中…