1-(2,4-Dichlorophenyl)-2-morpholin-4-ylethan-1-one → (2e)-1-(2,4-Dichlorophenyl)-3-(dimethylamino)-2-morpholin-4-ylprop-2-en-1-one

HRID 2297132ノート

反応式

HRID 2297132 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:17])[CH2:10][N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>CN(C(OC)OC)C>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:17])/[C:10](/[N:11]1[CH2:12][CH2:13][O:14][CH2:15][CH2:16]1)=[CH:10]\[N:11]([CH3:16])[CH3:12]

参加物

3

反応物 1

HCID 221428751-(2,4-Dichlorophenyl)-2-morpholin-4-ylethan-1-one

生成物 1

HCID 69308798(2e)-1-(2,4-Dichlorophenyl)-3-(dimethylamino)-2-morpholin-4-ylprop-2-en-1-one

試薬・触媒・溶媒 1

HCID 78373Dimethylformamide dimethyl acetal溶媒

実験手順

1 mmol of 1-(2,4-dichlorophenyl)-2-morpholin-4-ylethan-1-one was heated to 80° C. in N,N-dimethylformamidedimethyl acetal for six hours. The reaction mixture was concentrated in vacuo and purified by trituration: with diethyl ether to obtain (2E)-1-(2,4-dichlorophenyl)-3-(dimethylamino)-2-morpholin-4-ylprop-2-en-1-one.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. custompurified by trituration

出典と根拠

ORDレコード
ord-60d03fea7b2c45e39fe5a413034a728e
出典データセット
uspto-grants-2002_12
特許番号
US06489344B1

反応ノート

読み込み中…