Ammonium Hydroxide → 8-amino-1-{4-[(aminothio)peroxy]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide

HRID 22979ノート

反応式

HRID 22979 の反応式
[NH2:1][C:2]1[CH:29]=[CH:28][C:5]2[CH2:6][CH2:7][C:8]3[C:9]([C:23]([O:25]CC)=O)=[N:10][N:11]([C:13]4[CH:18]=[CH:17][C:16]([O:19][O:20][S:21][NH2:22])=[CH:15][CH:14]=4)[C:12]=3[C:4]=2[CH:3]=1.[OH-].[NH4+:31]>CO>[NH2:1][C:2]1[CH:29]=[CH:28][C:5]2[CH2:6][CH2:7][C:8]3[C:9]([C:23]([NH2:31])=[O:25])=[N:10][N:11]([C:13]4[CH:14]=[CH:15][C:16]([O:19][O:20][S:21][NH2:22])=[CH:17][CH:18]=4)[C:12]=3[C:4]=2[CH:3]=1

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 22592527Ethyl 8-amino-1-{4-[(aminothio)peroxy]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxylate

生成物 1

HCID 222915508-amino-1-{4-[(aminothio)peroxy]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The product of Example 4a (968 mg), conc. ammonium hydroxide (10 mL), and methanol (5 mL) were heated at 95° C. in a sealed pressure bottle for 16 h. The mixture was allowed to cool and let stand for 3 h. The resulting amber solid was collected by filtration to yield the title compound (630 mg).

後処理

  1. temperatureto cool
  2. filtrationThe resulting amber solid was collected by filtration

出典と根拠

ORDレコード
ord-86bb77d9810b42b8954414a4824e376e
出典データセット
uspto-grants-2005_02
特許番号
US06849653B2

反応ノート

読み込み中…