Hydrochloric Acid → (2S)-4-(acetyloxy)-2-(2,2,2-trifluoroacetamido)butanoic acid

HRID 2298548ノート

反応式

HRID 2298548 の反応式
C(=O)([O-])[O-].[K+].[K+].Cl.[C:8]([O:11][CH2:12][CH2:13][C@@H:14]([C:16]([OH:18])=[O:17])[NH2:15])(=[O:10])[CH3:9].C(OC(=O)C[C:24](=[O:29])[C:25]([F:28])([F:27])[F:26])C.Cl>C(O)C.O>[F:26][C:25]([F:28])([F:27])[C:24]([NH:15][C@H:14]([C:16]([OH:18])=[O:17])[CH2:13][CH2:12][O:11][C:8](=[O:10])[CH3:9])=[O:29]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 67793Ethyl 4,4,4-trifluoroacetoacetateHCID 45038083O-Acetyl-L-homoserine hydrochloride

生成物 1

HCID 53989376(2S)-4-(acetyloxy)-2-(2,2,2-trifluoroacetamido)butanoic acid収率 45.1%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

7.6 g (55 mol) of potassium carbonate are added to a suspension of 9.9 g (50 mmol) of O-acetyl-L-homoserine hydrochloride and 7.8 g (55 mmol) of trifluoroacetylacetic acid ethyl ester in 200 ml of ethanol, and stirring is carried out for 14 hours. 10.8 g (110 mmol) of 37% hydrochloric acid and 200 ml of water are then added. The product obtained after removal of the ethanol by distillation is filtered off with suction, washed with water and dried. 5.8 g (45%) of N-trifluoroacetyl-O-acetyl-L-homo-serine are obtained.

後処理

  1. customThe product obtained
  2. customafter removal of the ethanol
  3. distillationby distillation
  4. filtrationis filtered off with suction
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-709a559984004df2a1237fba515d1dd0
出典データセット
uspto-grants-2002_12
特許番号
US06492541B2

反応ノート

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