化工社化工社 化学情報印刷レポート · 研究参考用
Methyl acetoacetate → 5-(2-Fluoro-5-trifluoromethyl-phenyl)-2-methyl-1-[2-(tetrahydro-pyran-4-yl)-ethyl]-1H-pyrrole-3-carboxylic acid cyclohexylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl acetoacetate | HCID 7757 | — |
| 反応物 | Cyclohexylamine | HCID 7965 | — |
| 反応物 | 2-(Oxan-4-yl)ethan-1-amine | HCID 2773198 | — |
| 反応物 | 2-Fluoro-5-(trifluoromethyl)phenacyl bromide | HCID 2778784 | — |
| 生成物 | 5-(2-Fluoro-5-trifluoromethyl-phenyl)-2-methyl-1-[2-(tetrahydro-pyran-4-yl)-ethyl]-1H-pyrrole-3-carboxylic acid cyclohexylamide | HCID 11670194 | — |
反応手順
The title compound was synthesized in analogy to example 7, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-[2-fluoro-5-(trifluoromethyl)-phenyl]-ethanone as compound of formula S, 4-(2-aminoethyl)-tetrahydropyrane as R3—(CH2)m—NH2 and 1-cyclohexylamine as R1R2NH, MS (ISP) 481.6 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07563910B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-160b7fc496ff49f9bcfcc6341de018a7 |
| 出典メモ | uspto-grants-2009_07 |