Methyl acetoacetate → 2-[5-(5-Chloro-2-fluoro-phenyl)-3-cyclohexylcarbamoyl-2-methyl-pyrrol-1-ylmethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

反応式

CO[C:3](=[O:8])[CH2:4][C:5](=O)[CH3:6].Br[CH2:10][C:11]([C:13]1[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=1[F:20])=O.[C:21]([O:25][C:26]([N:28]1[CH2:32][CH2:31][CH2:30][C@@H:29]1[CH2:33][NH2:34])=[O:27])([CH3:24])([CH3:23])[CH3:22].[CH:35]1([NH2:41])[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]1>>[C:21]([O:25][C:26]([N:28]1[CH2:32][CH2:31][CH2:30][CH:29]1[CH2:33][N:34]1[C:11]([C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=2[F:20])=[CH:10][C:4]([C:3](=[O:8])[NH:41][CH:35]2[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]2)=[C:5]1[CH3:6])=[O:27])([CH3:24])([CH3:23])[CH3:22]