化工社化工社 化学情報印刷レポート · 研究参考用
Methyl acetoacetate → (Rac)-5-(2-chloro-5-trifluoromethyl-phenyl)-1-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-2-methyl-1h-pyrrole-3-carboxylic acid cyclohexylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl acetoacetate | HCID 7757 | — |
| 反応物 | Cyclohexylamine | HCID 7965 | — |
| 反応物 | 2-Chloro-5-(trifluoromethyl)phenacyl bromide | HCID 2783183 | — |
| 反応物 | 1,3-Dioxolane-4-methanamine, 2,2-dimethyl- | HCID 4122349 | — |
| 生成物 | (Rac)-5-(2-chloro-5-trifluoromethyl-phenyl)-1-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-2-methyl-1h-pyrrole-3-carboxylic acid cyclohexylamide | HCID 11698963 | — |
反応手順
The title compound was synthesized in analogy to example 7, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-[2-chloro-5-(trifluoromethyl)-phenyl]-ethanone as compound of formula S, 2,2-dimethyl-1,3-dioxolan-4-methylamine as R3—(CH2)m—NH2 and 1-cyclohexylamine as R1R2NH, MS (ISP) 499.4 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07563910B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-636f9d7eb59c48f9b8bc1089236cbbe3 |
| 出典メモ | uspto-grants-2009_07 |