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Methyl acetoacetate → 5-(2-Chloro-5-trifluoromethyl-phenyl)-1-(rac)-[1,4]dioxan-2-ylmethyl-2-methyl-1h-pyrrole-3-carboxylic acid ((1r,2r)-2-hydroxy-cyclohexyl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl acetoacetate | HCID 7757 | — |
| 反応物 | (1R,2R)-2-Aminocyclohexanol | HCID 735777 | — |
| 反応物 | 2-Chloro-5-(trifluoromethyl)phenacyl bromide | HCID 2783183 | — |
| 反応物 | 1,4-Dioxan-2-ylmethanamine | HCID 3748064 | — |
| 生成物 | 5-(2-Chloro-5-trifluoromethyl-phenyl)-1-(rac)-[1,4]dioxan-2-ylmethyl-2-methyl-1h-pyrrole-3-carboxylic acid ((1r,2r)-2-hydroxy-cyclohexyl)-amide | HCID 11576955 | — |
反応手順
The title compound was synthesized in analogy to example 7, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-[2-chloro-5-(trifluoromethyl)-phenyl]-ethanone as compound of formula S, 1,4-dioxane-2-methanamine as R3—(CH2)m—NH2 and (1R,2R)-2-aminocyclohexanol as R1R2NH, MS (ISP) 501.4 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07563910B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-7677928d7be9466eab4c3a36cba5cc17 |
| 出典メモ | uspto-grants-2009_07 |