Morpholine → 2-(morpholin-4-yl)-4-nitro-1H-benzimidazole

HRID 2298812ノート

反応式

HRID 2298812 の反応式
Cl[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:4]=2[N:3]=1.[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1.C(=O)([O-])O.[Na+]>>[N:14]1([C:2]2[NH:6][C:5]3[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:4]=3[N:3]=2)[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

参加物

4

反応物 3

HCID 8083MorpholineHCID 516892Sodium BicarbonateHCID 14765451HCID 14765451、化合物

生成物 1

HCID 183786202-(morpholin-4-yl)-4-nitro-1H-benzimidazole

反応条件

温度
50 °C

実験手順

A mixture of 2-chloro-4-nitro-1H-benzimidazole (300 mg) and morpholine (1 ml) was stirred at 50° C. for 8 hours. The reaction mixture was poured into saturated aqueous sodium hydrogencarbonate solution and extracted with chloroform. The organic layer was washed with brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo. The residue was washed with isopropyl ether and collected by vacuum filtration to give 2-(morpholin-4-yl)-4-nitro-1H-benzimidazole (288 mg).

後処理

  1. extractionextracted with chloroform
  2. washThe organic layer was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. customThe solvent was evaporated in vacuo
  5. washThe residue was washed with isopropyl ether
  6. filtrationcollected by vacuum filtration

出典と根拠

ORDレコード
ord-1974a1f013ee4591b081c81e72c586ad
出典データセット
uspto-grants-2002_12
特許番号
US06495542B1

反応ノート

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