関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Ibandronate | HCID 60852 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Ibandronate Sodium Anhydrous | HCID 23670359 | 93.6% |
反応手順
A solution of amorphous ibandronic acid (2.7 g) in water (25 ml) and sodium hydroxide (0.34 g, solid) was stirred at 70° C. The solution was poured into cold IPA (500 ml). The resulting precipitate was stirred at 0° C. for 16 hours. The precipitate was isolated by vacuum filtration and dried in a vacuum oven at 50° C. for 24 hours to obtain 2.7 g of ibandronate sodium crystal form K3. Form K3 can exhibit a weight loss of about 7% to about 8% in TGA.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07563918B2 |
|---|
| 出典データセット | uspto-grants-2009_07 |
|---|
| ORD ID | ord-df61eb585e5741eda33bb880dec71106 |
|---|
| 出典メモ | uspto-grants-2009_07 |
|---|
