Dimethylformamide → 2-Bromo-1-(3-methylbut-2-enylthio)benzene

HRID 22991

反応式

HRID 22991 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[SH:8].CN(C=O)C.C(=O)([O-])[O-].[K+].[K+].Br[CH2:21][CH:22]=[C:23]([CH3:25])[CH3:24]>O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][CH2:21][CH:22]=[C:23]([CH3:25])[CH3:24]

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 700922-Butene, 1-bromo-3-methyl-HCID 805982-Bromobenzenethiol

生成物 1

HCID 106348752-Bromo-1-(3-methylbut-2-enylthio)benzene

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

19.30 g (102.0 mmol) of 2-bromothiophenol, 160 ml of DMF and 15.50 g (112.0 mmol) of potassium carbonate are introduced into a three-necked flask. 13 ml (112.0 mmol) of 1-bromo-3-methyl-2-butene are added dropwise and the reaction mixture is stirred at room temperature for two hours. It is poured into water and extracted with ethyl acetate and the organic phase is separated by settling, washed with water, dried over magnesium sulphate and evaporated. 26.00 g (99%) of the expected compound are collected in the form of an orangey oil.

後処理

  1. extractionextracted with ethyl acetate
  2. customthe organic phase is separated
  3. washwashed with water
  4. dry with materialdried over magnesium sulphate
  5. customevaporated
  6. custom26.00 g (99%) of the expected compound are collected in the form of an orangey oil

出典と根拠

ORDレコード
ord-cc4dd4a925134e97806965f18a207e98
出典データセット
uspto-grants-2005_02
特許番号
US06849658B2

関連ノート

読み込み中…