Dimethyl Pentadecanedioate → Methyl 15-Hydroxypentadecanoate

HRID 2299573

反応式

HRID 2299573 の反応式
[C:1](OC)(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH3:18])=[O:16].[H][H]>>[OH:19][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH3:18])=[O:16]

参加物

3

反応物 2

HCID 11415366Dimethyl PentadecanedioateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 3496889Methyl 15-Hydroxypentadecanoate収率 61%

実験手順

150 g (499 mmol) of dimethyl 1,15-pentadecandioate and 12 g (8.0% by weight per the diester) of the catalyst prepared in Preparative Example 1 were added to an autoclave and subjected to hydrogenation reaction at the hydrogen pressure of 20.0 Mpa at 250° C. After 8 hours, the degree of the conversion was 63% and the selectivity was 87%. The reaction was further continued, and after 10 hours, methyl 15-hydroxypentadecanoate was obtained in 61% yield. The results are shown in Table 2.

後処理

  1. additionwere added to an autoclave
  2. waitafter 10 hours

出典と根拠

ORDレコード
ord-0eebe7be8f0446008ebcfbaa888f6a73
出典データセット
uspto-grants-2002_12
特許番号
US06495706B2

関連ノート

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