6-hydroxy-1,4-naphthoquinone → HCID 18376526、化合物

HRID 2300577ノート

反応式

HRID 2300577 の反応式
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[CH:7]=[CH:6][C:5]2=[O:13]>CO>[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[C:7]([C:9]([CH3:10])([CH3:4])[CH:8]=[O:12])=[CH:6][C:5]2=[O:13]

参加物

3

反応物 1

HCID 118195036-hydroxy-1,4-naphthoquinone2 回

生成物 1

HCID 18376526HCID 18376526、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

6-Hydroxynaphthoquinone (compound 2 prepared in step I above) (0.74 g, 2.35 mmol) was dissolved in 75% MeOH (30 mL) and powdered FeCl3·6H2O (1.65 g, 6.1 mmol) was added. The mixture was stirred for 4 h. The solvent was evaporated and the crude product (compound 3) was purified on silica gel with hexane:EtOAc 4:1. Yield: 0.27 g (47%). 1H NMR (400 MHz, Acetone-d6) δ 1.36 (s, 6 H), 6.90 (s, 1 H), 7.24 (dd, 1 H), 7.39 (d, 1 H), 7.94 (d, 1 H), 9.64 (s, 1 H).

後処理

  1. customThe solvent was evaporated
  2. customthe crude product (compound 3) was purified on silica gel with hexane:EtOAc 4:1

出典と根拠

ORDレコード
ord-ba99adc3743d447e9a6dd6fb00de5f82
出典データセット
uspto-grants-2002_12
特許番号
US06498182B2

反応ノート

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