Bromine → Ethyl 6-bromo-6-(4-chlorobenzoyl)hexanoate

HRID 2300669ノート

反応式

HRID 2300669 の反応式
[Br:1]Br.[Cl:3][C:4]1[CH:21]=[CH:20][C:7]([C:8]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:9])=[CH:6][CH:5]=1>ClCCl>[Br:1][CH:10]([C:8](=[O:9])[C:7]1[CH:6]=[CH:5][C:4]([Cl:3])=[CH:21][CH:20]=1)[CH2:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16]

参加物

4

反応物 2

HCID 24408BromineHCID 11065929Ethyl 7-(4-chlorophenyl)-7-oxoheptanoate

生成物 1

HCID 11810554Ethyl 6-bromo-6-(4-chlorobenzoyl)hexanoate収率 99.8%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Bromine(21.1 g) was added dropwise to a dichloromethane solution (200 ml) of ethyl 6-(4-chlorobenzoyl)hexanoate (37.3 g) at room temperature. After stirring for 30 minutes, the reaction mixture was washed with sodium hydrogensulfite, saturated sodium bicarbonate and water in turn. The dichloromethane layer was dried(MgSO4). The solvent was evaporated to give ethyl 6-bromo-6-(4-chlorobenzoyl)hexanoate(47.6 g, quant.) as an oily substance.

後処理

  1. washthe reaction mixture was washed with sodium hydrogensulfite, saturated sodium bicarbonate and water in turn
  2. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-36616594bbb44475a902eccb52f28337
出典データセット
uspto-grants-2002_12
特許番号
US06498179B1

反応ノート

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