2-Bromobenzylamine → 2-[2-Bromobenzylamino]-4-[benzimidazol-1-yl]pyrimidine

HRID 2300750

反応式

HRID 2300750 の反応式
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[Br:20][C:21]1[CH:28]=[CH:27][CH:26]=[CH:25][C:22]=1[CH2:23][NH2:24]>>[Br:20][C:21]1[CH:28]=[CH:27][CH:26]=[CH:25][C:22]=1[CH2:23][NH:24][C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1

参加物

3

反応物 2

HCID 3340722-BromobenzylamineHCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

生成物 1

HCID 183756732-[2-Bromobenzylamino]-4-[benzimidazol-1-yl]pyrimidine

実験手順

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with 2-bromobenzylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (CI): m/e 380.2, 382.2 (M+1). 1H NMR (500 MHz, CDCl3): δ partial 8.60 (s, 1H); 8.44 (br s, 1H); 8.02 (br s, 1H); 7.85 (m, 1H); 7.64 (d, J=5.6 Hz, 1H); 7.48 (d, J=7.3 Hz, 1H); 7.18 (m, 1H); 6.86 (d, J=5.5 Hz, 1H); 6.18 (br s, 1H); 4.83 (d, J=6.4 Hz, 2H).

出典と根拠

ORDレコード
ord-b7f7813d852f46d6a0172b40532a9a3b
出典データセット
uspto-grants-2002_12
特許番号
US06498165B1

関連ノート

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