反応式
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[NH2:20][CH2:21][CH:22]1[CH2:24][CH2:23]1>>[CH:22]1([CH2:21][NH:20][C:5]2[N:10]=[C:9]([N:11]3[C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=4[N:13]=[CH:12]3)[CH:8]=[CH:7][N:6]=2)[CH2:24][CH2:23]1参加物
3
実験手順
2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with aminomethylcyclopropane according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (CI): 266.1 (M+1). 1H NMR (500 MHz, CDCl3): δ 8.65 (s, 1H); 8.38 (br s, 1H); 8.23 (d, J=7.8 Hz, 1H); 7.88 (d, J=7.8 Hz, 1H); 7.42 (m, 2H); 6.82 (d, J=5.5 Hz, 1H); 5.30-6.25 (br, 1H); 3.42 (br s, 2H); 1.19 (br s, 1H); 0.62 (m, 2H); 0.35 (m, 2H).
出典と根拠
- ORDレコード
- ord-5a94703959234673a0ae186a66c356d5
- 出典データセット
- uspto-grants-2002_12
- 特許番号
- US06498165B1
関連ノート
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