関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Chloro-N,N-dimethylformiminium chloride | HCID 77311 | — |
| 反応物 | HCID 178477341 | HCID 178477341 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 4-Chloro-2-(ethylthio)pyrimidine-5-carbonitrile | HCID 18375395 | 60.3% |
反応手順
To a solution of 2-ethylthio-4-hydroxy-5-cyanopyrimidine (196 mg, 1.08 mmol) in 1,4-dioxane (5 mL) was added (chloro-methylene)dimethylammonium chloride (550 mg, 4.32 mmol). The mixture was heated at 100° C. for 4 h, cooled, and the solvent was removed under reduced pressure. The crude material was purified by flash chromatography using 1:20 acetone:hexane system to yield 130 mg of the title compound. Mass spectrum 199.3 (EI, M+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06498165B1 |
|---|
| 出典データセット | uspto-grants-2002_12 |
|---|
| ORD ID | ord-24b5f1748416463f96734d0ff44993bb |
|---|
| 出典メモ | uspto-grants-2002_12 |
|---|
