Cyclopropaneacetic acid → N-(Cyclopropylacetyl)-L-alanine
反応式
[CH:1]1([CH2:4][C:5]([OH:7])=O)[CH2:3][CH2:2]1.Cl.C[O:10][C:11](=[O:15])[C@H:12]([CH3:14])[NH2:13]>>[CH:1]1([CH2:4][C:5]([NH:13][C@H:12]([C:11]([OH:15])=[O:10])[CH3:14])=[O:7])[CH2:2][CH2:3]1参加物
3
実験手順
Following General Procedure II-E above using cyclopropylacetic acid (Aldrich) and L-alanine methyl ester hydrochloride (Sigma), the title compound was prepared as an oil. The reaction was monitored by tlc on silica gel (Rf=0.15 in 25% ethyl acetate/hexanes) and purification was by flash column chromatography using 25% ethyl acetate/hexanes as the eluant.
後処理
- customThe reaction was monitored by tlc on silica gel (Rf=0.15 in 25% ethyl acetate/hexanes) and purification
出典と根拠
- ORDレコード
- ord-c1aa1f135199484289799d0967d68dae
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06849650B2
反応ノート
読み込み中…