関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Urea | HCID 1176 | — |
| 反応物 | Benzoic acid, 2-amino-5-iodo- | HCID 72911 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 6-iodo-1H-quinazoline-2,4-dione | HCID 11380668 | 87.4% |
反応手順
A mixture of 2-amino-5-iodobenzoic acid (3.5 g) and urea (1.56 g) in NMP (15 ml) was heated at 160° C. for 6 hours then cooled. Water (200 ml) was added and the resultant precipitate was collected, washed with water and dried to give the title compound (3.35 g) as a solid. MS (CI): 289 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06498275B1 |
|---|
| 出典データセット | uspto-grants-2002_12 |
|---|
| ORD ID | ord-55b39c4db08a431c9102d98fe03163de |
|---|
| 出典メモ | uspto-grants-2002_12 |
|---|
