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Dimethylformamide → 1,3-Dimethyl-6-iodoquinazolinedione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 6-iodo-1H-quinazoline-2,4-dione | HCID 11380668 | — |
| 生成物 | 1,3-Dimethyl-6-iodoquinazolinedione | HCID 22287364 | — |
反応手順
Sodium hydride (0.24 g of a 60% dispersion in oil) was added portionwise to a stirred solution of 6-iodoquinazolinedione (0.58 g) (Method 53) and iodomethane (0.63 ml) in DMF (10 ml). The mixture was stirred for 1 hour then added cautiously to saturated aqueous ammonium chloride solution (200 ml). Extraction with ethyl acetate followed by recrystallization from ethanol plus a little chloroform gave the title compound (0.48 g) as a solid. MS (CI+): 317 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06498275B1 |
| 出典データセット | uspto-grants-2002_12 |
| ORD ID | ord-8ba1342a0d8e434cbc95233b6fc7fd11 |
| 出典メモ | uspto-grants-2002_12 |