Hydrochloric Acid → 4-(2,3-Dihydro-1H-inden-1-yl)piperidine--hydrogen chloride (1/1)

HRID 2301147ノート

反応式

HRID 2301147 の反応式
[ClH:1].O[C:3]1([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4]1>[Pt]=O.C(O)C>[ClH:1].[CH:3]1([CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 2971671-hydroxy-1-(4-pyridyl)indan

生成物 1

HCID 223805864-(2,3-Dihydro-1H-inden-1-yl)piperidine--hydrogen chloride (1/1)

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒

実験手順

Ethanol (20 ml), concentrated hydrochloric acid (0.5 ml) and platinum oxide (50 mg) were added to 1-hydroxy-1-pyridin-4-yl-indane (540 mg, 2.6 mmol), and catalytic reduction was carried out at ordinary temperature under ordinary pressure to obtain 420 mg (2.1 mmol, 62% in yield) of the title compound as crystals.

後処理

  1. customto obtain

出典と根拠

ORDレコード
ord-e0031719324242eea0a2ca2625ee5301
出典データセット
uspto-grants-2002_12
特許番号
US06498251B1

反応ノート

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