Boron tribromide → HCID 18372893、化合物

反応式

[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[O:11][C:12]4[C:17]([C:18](=[O:21])[C:19]=3[OH:20])=[CH:16][C:15]([O:22][CH3:23])=[CH:14][CH:13]=4)=[CH:9][C:4]=2[O:3]C1.B(Br)(Br)Br>>[OH:3][C:4]1[CH:9]=[C:8]([C:10]2[O:11][C:12]3[C:17]([C:18](=[O:21])[C:19]=2[OH:20])=[CH:16][C:15]([O:22][CH3:23])=[CH:14][CH:13]=3)[CH:7]=[CH:6][C:5]=1[OH:1]

参加物

反応物 2

HCID 25134Boron tribromide

HCID 18372877HCID 18372877、化合物

生成物 1

HCID 18372893HCID 18372893、化合物収率 58,648,816%

実験手順

The reaction was conducted according to the same procedure as Example 57 except that 50 mg (159 pmol) of the compound obtained in Example 5 instead of the compound obtained in Example 12 and 1.5 molar equivalents of boron tribromide (BBr3) were used. Then the resulting product was separated by preparative TLC to give 28 mg of the title compound in a yield of 60%.

後処理

customThen the resulting product was separated by preparative TLC

出典と根拠

ORDレコード: ord-d8e7ca0db34445468cac6ae932a858d2
出典データセット: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06500846B1

反応ノート

読み込み中…

参加物