Boron tribromide → HCID 18372862、化合物

HRID 2301354ノート

反応式

HRID 2301354 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[O:11][C:12]4[C:17]([C:18](=[O:21])[C:19]=3[OH:20])=[C:16]([O:22][CH3:23])[CH:15]=[CH:14][CH:13]=4)=[CH:9][C:4]=2[O:3]C1.B(Br)(Br)Br>>[OH:3][C:4]1[CH:9]=[C:8]([C:10]2[O:11][C:12]3[C:17]([C:18](=[O:21])[C:19]=2[OH:20])=[C:16]([O:22][CH3:23])[CH:15]=[CH:14][CH:13]=3)[CH:7]=[CH:6][C:5]=1[OH:1]

参加物

3

反応物 2

HCID 25134Boron tribromideHCID 98397442-(Benzo[1,3]dioxol-5-yl)-3-hydroxy-5-methoxy-chromen-4-one

生成物 1

HCID 18372862HCID 18372862、化合物収率 40,315,552%

実験手順

The reaction was conducted according to the same procedure as Example 57 except that 60 mg (190 pmol) of the compound obtained in Example 4 instead of the compound obtained in Example 12 and 1.5 molar equivalents of boron tribromide (BBr3) were used. Then the resulting product was separated by preparative TLC to give 23 mg of the title compound in a yield of 40%.

後処理

  1. customThen the resulting product was separated by preparative TLC

出典と根拠

ORDレコード
ord-5c2757a6cef243a382d8ab72d0febe8f
出典データセット
uspto-grants-2002_12
特許番号
US06500846B1

反応ノート

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