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3,5-Difluorophenylacetic acid → (S)-2-[1-(3,5-difluorophenylacetamido)ethyl]-4-ethoxycarbonyl-2-thiazoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,5-Difluorophenylacetic acid | HCID 145424 | — |
| 反応物 | (S)-2-(1-aminoethyl)-4-ethoxycarbonyl-2-thiazoline hydrochloride | HCID 69741166 | — |
| 生成物 | (S)-2-[1-(3,5-difluorophenylacetamido)ethyl]-4-ethoxycarbonyl-2-thiazoline | HCID 69743302 | — |
反応手順
Following General Procedure A above and using 3,5-difluorophenylacetic acid (Aldrich) and (S)-2-(1-aminoethyl)-4-ethoxycarbonyl-2-thiazoline hydrochloride (Example G), the title compound was prepared as a semisolid. The reaction was monitored by tlc (Rf=0.2 in 1:1 EtOAc/hexanes) and the product was purified by silica gel chromatography using 1:1 EtOAc/hexanes as the eluent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06849650B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-4b5f11cfbb094dedbb3d02741f1c7ebc |
| 出典メモ | uspto-grants-2005_02 |