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3,5-Difluorophenylacetic acid → (s)-2-[1-(3,5-Difluorophenylacetamido)ethyl]-5(r,s)-ethoxycarbonyl-2-oxazoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,5-Difluorophenylacetic acid | HCID 145424 | — |
| 反応物 | (s)-2-(1-Aminoethyl)-5(r,s)-ethoxycarbonyl-2-oxazoline | HCID 131723742 | — |
| 溶媒 | Chloroform methanol | HCID 21584188 | — |
| 生成物 | (s)-2-[1-(3,5-Difluorophenylacetamido)ethyl]-5(r,s)-ethoxycarbonyl-2-oxazoline | HCID 131723741 | — |
反応手順
Following General Procedure A and using 3,5-difluorophenylacetic acid (Aldrich) and (S)-2-(1-aminoethyl)-5(R,S)-ethoxycarbonyl-2-oxazoline (Example F), the title compound was prepared as a semisolid. The reaction was monitored by tlc (Rf=0.3 in 5% MeOH/CHCl3) and the product was purified by silica gel chromatography using 5% MeOH/CHCl3 as the eluent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06849650B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-c299ca4730364ed6b87f71d07b1e409a |
| 出典メモ | uspto-grants-2005_02 |