Hydrochloric Acid → HCID 18677713、化合物

HRID 2301753ノート

反応式

HRID 2301753 の反応式
Cl.C([Cl:5])(=O)C.[CH2:6]([O:13][C:14]([N:16]([CH:20]1[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]1)[CH2:17][CH2:18][CH3:19])=[O:15])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(OCC)(=O)C>CO>[ClH:5].[CH2:6]([O:13][C:14]([N:16]([CH:20]1[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]1)[CH2:17][CH2:18][CH3:19])=[O:15])[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 8857Ethyl AcetateHCID 186776841,1-Dimethylethyl 4-[[(phenylmethoxy)carbonyl]propylamino]-1-piperidinecarboxylate

生成物 1

HCID 18677713HCID 18677713、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 2.4 mmol of HCl in 2 mL of methanol (prepared by the addition of 0.17 mL of acetyl chloride at 0° C. and stirring for 10 min) was added 90 mg of 4-(N-(benzyloxycarbonyl)-N-(prop-1-yl)amino)-1-t-butoxycarbonylpiperidine. The mixture was stirred at rt for 16 h at which time the reaction was complete by TLC (20% ethyl acetate in hexanes) and was evaporated to dryness in vacuo to afford 75 mg of the title compound as the hydrochloride salt.

後処理

  1. stirringThe mixture was stirred at rt for 16 h at which time the reaction
  2. customwas evaporated to dryness in vacuo

出典と根拠

ORDレコード
ord-1582f23a9f554cf6b8fcc8c7eb9f8182
出典データセット
uspto-grants-2002_12
特許番号
US06500844B1

反応ノート

読み込み中…